The endocannabinoid system (ECS) is a biological system involving receptor proteins that are expressed throughout the  central nervous system and peripheral nervous system.

In humans and other mammals, the ECS  is involved in regulating a variety of physiological and cognitive processes, in mediating some of the physiological and cognitive effects of physical exercise.

Two primary endocannabinoid receptors have been identified. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues. CB2 receptors are involved in the regulation of appetite, immune system functions and pain management.

The body naturally produces cannabinoids that share chemical structures similar to cannabinoids derived from plants like CBD.